Testosterone risk taking

Testosterone is a hormone that is produced primarily in the testicles for men and the ovaries and adrenal glands for women. This hormone is essential to the development of male growth and masculine characteristics. For women, testosterone comes in much smaller amounts. Testosterone production increases about 30 times more during adolescence and early adulthood. After early adulthood, it’s natural for levels to drop slightly each year. Your body may see a one percent decline after you’re 30 years old.

Testosterone plays a key role in your:

In general, Bhasin says, doctors should give more information to patients considering the treatments. For example, he says, "doctors don’t tell you that testosterone supplements may end up a long-term proposition." When men begin using a supplement, he explains, they typically lose the ability to create testosterone on their own. So if a health problem should arise that forces them to stop taking the supplements, it may take months or years to recover the ability to create adequate levels of testosterone naturally, during which time they may experience withdrawal symptoms like poor mood and low vitality.
 
“I find it very distressing that testosterone is used in middle-aged men — when we don’t know whether it’s even safe — for something that may be a normal physiologic adaptive mechanism to aging," he says.
 
Both experts agree that men with a history of heart attack or stroke should steer clear of testosterone supplements. They also agree that there are scenarios in which the benefits of testosterone therapy nearly always outweigh the risks, like hypogonadism, a disease in which the body produces little or no hormone due to poorly functioning testes or pituitary or hypothalamus glands.

A recent case of a 51 year old male with an interest in testosterone replacement illustrates the benefits of the multi-parametric prostate MRI scan. Noting a PSA value of only ng/ml; the digital rectal exam (DRE) identified an area of interest on the left side, albeit, it was not definitive for prostate cancer. Neither the gray scale ultrasound nor Color Flow Doppler ultrasound evaluation suggested any specific abnormality consistent with the area of interest previously identified on DRE. An MRI scan was suggested as the next best step in the evaluation. The scan isolated a region of interest on the left side at the Apex to Middle portion of the prostate gland concordant with the findings on the DRE.  Based upon the findings of the MRI scan, a targeted biopsy with 6 needle cores was recommended and implemented. An Antiandrogen was initiated pre-biopsy to mitigate against “needle tracking”. Specifically, an Antiandrogen selectively blocks the receptor on the prostate cell from attracting testosterone as it exits the capsule, thereby, disabling the cells in preparation for cell death or apoptosis. The Pathology evaluation revealed a grade of cancer that was amenable to being treated conservatively or focally. In this case, the failure to use a MRI scan would have exposed this patient to the possibility of missing the cancer altogether; associated with sampling bias, a very real possibility for needle tracking (assuming cancer was found), or worse yet, the go ahead to supplement with testosterone, when in fact, the cancer was missed. Using  testosterone in this scenario would have stimulated cancer cells to grow wildly, while causing the PSA to spike abnormally, thereby, making the diagnosis of prostate cancer – a potentially uncontrollable clinical event, albeit, avoidable. Given the expertise of a Urolologic consultation, this case turned out well. The patient is now contemplating a focal treatment with high intensity focused ultrasound with a plan to supplement with testosterone once his cancer has been cured. An inability to document the resolution of prostate cancer by a repeat MRI scan and/or a stable PSA post-operatively will preclude this patient from using testosterone replacement therapy.

Kraft, S. (.). Signs of high testosterone in women. Retrieved from  http:///content/article/signs-high-testosterone-women

Low testosterone. (2012, March). Retrieved from  http:///diseases-and-conditions/mens-health/low-testosterone

Nigro, N. & Christ-Cain, M. (2012). Testosterone treatment in the aging male: Myth or reality? Swiss Medicine Weekly, 2012(142), w13539. Retrieved from  http:///content/smw-2012-13539/

NIH-supported trials of testosterone therapy in older men report mixed results. (2017, February 21). Retrieved from  https:///news-events/news-releases/nih-supported-trials-testosterone-therapy-older-men-report-mixed-results

Sharma, R., Oni, O. A., Gupta, K., Chen, G., Sharma, M., Dawn, B., … & Barua, R. S. (2015, August 6). Normalization of testosterone level is associated with reduced incidence of myocardial infarction. European Heart Journal, 36(40), 2706-2715. Retrieved from  https:///eurheartj/article/36/40/2706/2293361/Normalization-of-testosterone-level-is-associated

Sinicki, A. (.). What are prohormones? Are they safe? Retrieved from http:///entry/17328/1/What-Are-Prohormones-And-Are-They-

Testosterone and androgens. (2014, January). Retrieved from  http:///hormones-and-health/hormones/testosterone

Tsujimura, A. (2013, August 31). The relationship between testosterone deficiency and men's health.  The World Journal of Men's Health, 31 (2), 126-135. Retrieved from  http:///pmc/articles/PMC3770847/

Walker, W. H. (2010, May 27). Non-classical actions of testosterone and spermatogenesis.  Philosophical Transactions of the Royal Society of London Series B, 365 (1546). Retrieved from  http:///pmc/articles/PMC2871922/

Wein, H. (2013, September 23). Understanding how testosterone affects men. Retrieved from  https:///news-events/nih-research-matters/understanding-how-testosterone-affects-men

What is low testosterone (hypogonadism)? (.). Retrieved from  https:///urologic-conditions/low-testosterone-(hypogonadism)

Wong, J. Y. Y., Gold, E. B., Johnson, W. O., & Lee, J. S. (2015, October 2015). Circulating sex hormones and risk of uterine fibroids: Study of women's health across the nation (SWAN).  The Journal of Clinical Endocrinology & Metabolism, 101 (1), 123-130. Retrieved from  http:///doi//-2935

Ziegenfuss, T. N., Berardi, J. M., & Lowery, L. M. (2002, December). Effects of prohormone supplementation in humans: A review [Abstract]. Canadian Journal of Applied Physiology, 27 (6), 628-646. Retrieved from https:///pubmed/12501001

Testosterone risk taking

testosterone risk taking

Kraft, S. (.). Signs of high testosterone in women. Retrieved from  http:///content/article/signs-high-testosterone-women

Low testosterone. (2012, March). Retrieved from  http:///diseases-and-conditions/mens-health/low-testosterone

Nigro, N. & Christ-Cain, M. (2012). Testosterone treatment in the aging male: Myth or reality? Swiss Medicine Weekly, 2012(142), w13539. Retrieved from  http:///content/smw-2012-13539/

NIH-supported trials of testosterone therapy in older men report mixed results. (2017, February 21). Retrieved from  https:///news-events/news-releases/nih-supported-trials-testosterone-therapy-older-men-report-mixed-results

Sharma, R., Oni, O. A., Gupta, K., Chen, G., Sharma, M., Dawn, B., … & Barua, R. S. (2015, August 6). Normalization of testosterone level is associated with reduced incidence of myocardial infarction. European Heart Journal, 36(40), 2706-2715. Retrieved from  https:///eurheartj/article/36/40/2706/2293361/Normalization-of-testosterone-level-is-associated

Sinicki, A. (.). What are prohormones? Are they safe? Retrieved from http:///entry/17328/1/What-Are-Prohormones-And-Are-They-

Testosterone and androgens. (2014, January). Retrieved from  http:///hormones-and-health/hormones/testosterone

Tsujimura, A. (2013, August 31). The relationship between testosterone deficiency and men's health.  The World Journal of Men's Health, 31 (2), 126-135. Retrieved from  http:///pmc/articles/PMC3770847/

Walker, W. H. (2010, May 27). Non-classical actions of testosterone and spermatogenesis.  Philosophical Transactions of the Royal Society of London Series B, 365 (1546). Retrieved from  http:///pmc/articles/PMC2871922/

Wein, H. (2013, September 23). Understanding how testosterone affects men. Retrieved from  https:///news-events/nih-research-matters/understanding-how-testosterone-affects-men

What is low testosterone (hypogonadism)? (.). Retrieved from  https:///urologic-conditions/low-testosterone-(hypogonadism)

Wong, J. Y. Y., Gold, E. B., Johnson, W. O., & Lee, J. S. (2015, October 2015). Circulating sex hormones and risk of uterine fibroids: Study of women's health across the nation (SWAN).  The Journal of Clinical Endocrinology & Metabolism, 101 (1), 123-130. Retrieved from  http:///doi//-2935

Ziegenfuss, T. N., Berardi, J. M., & Lowery, L. M. (2002, December). Effects of prohormone supplementation in humans: A review [Abstract]. Canadian Journal of Applied Physiology, 27 (6), 628-646. Retrieved from https:///pubmed/12501001

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