Test replacement therapy

Natural, endogenous surfactant is a compound composed of phospholipids, neutral lipids, and proteins(1-5) that forms a layer between the alveolar surface and the alveolar gas and reduces alveolar collapse by decreasing surface tension within the alveoli.(3-5) Surfactant deficiency is almost always associated with the formation of hyaline membranes in the immature lung and the onset of respiratory distress syndrome (RDS)-a major cause of morbidity and mortality in premature infants.(3) Without surfactant, alveoli may never inflate or may collapse on expiration and require inordinate force to re-expand on inspiration, leading to the development of RDS.(3,5) The incidence of RDS is related more to lung immaturity than to gestational age.(6) However, in general, the more premature the infant, the less the surfactant production and the higher the probability for RDS.(4,6) Direct tracheal instillation of surfactant has been shown to reduce mortality and morbidity in infants with RDS.(7-25)

Test replacement therapy

test replacement therapy

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