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Other. In the group of patients whose vascular tone and renal function in predominantly depend on the activity of the renin-angiotensin-aldosterone system (patients with chronic heart failure III and stage IV [on classification NYHA] or with underlying renal disease, including renal artery stenosis ), treatment with angiotensin-converting enzyme inhibitors was associated with hypotension, azotemia, oliguria and, in rare cases with acute renal failure. As with other antihypertensive drugs, a significant reduction in blood pressure in patients with ischemic heart disease and / or atherosclerosis of cerebral vessels can lead to myocardial infarction or stroke. Treatment of such patients should be under the strict control of blood pressure.