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One of the reasons that low testosterone is so deadly is that it somehow effects almost all of the major cardiovascular markers. One recent large scale epidemiological study found that low testosterone men, < 250, were 1) fatter, 2) had lower HDL, 3) higher triglycerides, 4) higher blood pressure and 5) higher blood glucose .  That is a deadly combination! The low testosterone men were tracked over 18 years and it was found that they had a 40% higher death rate from all causes!