1: 13 of the 143 were receiving tacrine when evaluated.
2: 41 of the 172 were not receiving tacrine when evaluated.
The first column of the table is based on all patients participating in the study. The proportion provides an estimate of the likelihood that a patient entering the study will (1) still be on his or her assigned treatment at week 30 and (2) will improve 7 or more ADAS cognitive points over his or her baseline score. The estimate of response derived in this manner is conservative because the rules under which the 30-week study was conducted required the withdrawal of patients with relatively low (>3 X ULN), asymptomatic, transaminase elevations. In actual clinical practice under the conditions of treatment recommended in the Dosage and Administration Section, a larger fraction of these patients would be able to remain on tacrine and the proportion of those improving 7 or more points on tacrine would be expected, therefore, to be increased (the third column illustrates this).
The second column of the table presents the proportion of 7 unit responders based on the number of patients who (1) were able to complete the full 30 weeks of the study and (2) attained an ADAS cognitive score at week 30 that was 7 or more points better than their baseline score. This analysis provides an optimistic estimate of tacrine's effects because it reflects experience gained only with the minority of patients who were able to remain on treatment to the study's end. The comparison between the proportions of placebo and 160 mg patients attaining a 7 or more point improvement is complicated further by the fact that a larger proportion of tacrine assigned patients withdrew prematurely.
The third column of the table presents the proportion of patients who had evaluations made at 30 weeks and had a 7-point or greater response. The analysis includes data from patients still on their assigned treatment at week 30 as well as patients who withdrew from the study prior to that time, but were retrieved for a week 30 evaluation. Because patients who withdrew prior to week 30 were permitted to receive tacrine under "open label” conditions, retrieved patients included in this analysis could be receiving either no treatment or treatment with tacrine. In this analysis, patients are considered under the treatment to which they were randomized, regardless of the treatment they were actually receiving at week 30. Thus, some placebo patients could have received tacrine and some tacrine patients could have been receiving no tacrine. Like the analysis based on percent randomized (column I), this analysis, therefore, tends to provide a conservative view of the expected effects of tacrine treatment.
Producing Out-of-Body Experiences
Various hallucinogenic drugs, LSD included, will produce an out of body experience for the victim, if the drugs are administered correctly. The Programmer will prepare the victim with various information and story lines during the administration of the drug. Monarch slaves are being deprogrammed, they may have a memory where their skin feels inflamed and itchy, like a bad mosquito bite. The experience may also have the sensation of floating in an unreal world. This may well be an LSD trip given the slave during experimentation and programming. The CIA was using LSD beginning in the very early part of the 1950s. Several victims report that some type of potion causes a person to dream while they are awake. PCP which is “angel dust” is one way to disconnect the cortex from the limbic system and go into an altered state.
Serum lithium concentrations in uncomplicated cases receiving maintenance therapy during remission should be monitored at least every two months. Patients abnormally sensitive to lithium may exhibit toxic signs at serum concentrations of to mEq/L. Geriatric patients often respond to reduced dosage, and may exhibit signs of toxicity at serum concentrations ordinarily tolerated by other patients. In general, dose selection for an elderly patient should be cautious, usually starting at the low end of the dosing range, reflecting the greater frequency of decreased hepatic, renal, or cardiac function, and of concomitant disease or other drug therapy.