When tested in vitro , 7-keto appears to activate the beta subset of the estrogen receptor (ERβ) with an EC 50 around 500μM which is partially blocked by exemestane (aromatase inhibitor or AI); there was no apparent activity on the classical subset (ERα) and parent DHEA and DHEAS were eqipotent.  As activity was hindered with an AI and there was efficacy in HepG2 cells but not Hep293 (expressing  and not expressing  aromatase, respectively) it is though that 7-oxo can be metabolized into an estrogen. 
DHEA increases a brain chemical called serotonin. Some medications for depression also increase the brain chemical serotonin. Taking DHEA along with these medications for depression might increase serotonin too much and cause serious side effects including heart problems, shivering, and anxiety. Do not take DHEA if you are taking medications for depression.
Some of these medications for depression include fluoxetine ( Prozac ), paroxetine ( Paxil ), sertraline ( Zoloft ), amitriptyline ( Elavil ), clomipramine ( Anafranil ), imipramine ( Tofranil ), and others.