There is considerable controversy over the earliest age at which it is clinically, morally, and legally safe to use GnRH analogues, and for how long. The sixth edition of the World Professional Association for Transgender Health 's Standards of Care permit it from Tanner stage 2 but do not allow the addition of hormones until age 16, which could be five or more years later. Sex steroids have important functions in addition to their role in puberty, and some skeletal changes (such as increased height) that may be considered masculine are not hindered by GnRH analogues.
late 14c., "males or females collectively," from Latin sexus "a sex, state of being either male or female, gender," of uncertain origin. "Commonly taken with seco as division or 'half' of the race" [Tucker], which would connect it to secare "to divide or cut" (see section (n.)). Meaning "quality of being male or female" first recorded 1520s. Meaning "sexual intercourse" first attested 1929 (in writings of . Lawrence); meaning "genitalia" is attested from 1938. Sex appeal attested by 1904. For the raw sex appeal of the burlesque "shows" there is no defense, either. These "shows" should be under official supervision, at the least, and boys beneath the age of eighteen forbidden, perhaps, to attend their performance, just as we forbid the sale of liquors to minors. [Walter Prichard Eaton, "At the New Theatre and Others: The American Stage, Its Problems and Performances," Boston, 1910] Sex drive is from 1918; sex object is 1901; sex symbol is 1871 in anthropology; the first person to whom the term was applied seems to have been Marilyn Monroe (1959). Sex therapist is from 1974.