In the traditional tests for antipsychotic effect, eg antagonism of stereotypic behaviour induced by dopamine agonists, the chemical groups of antipsychotics mentioned reveal equal but dosage-dependent activity. However, the antistereotypic effects of phenothiazines, butyrophenones, diphenylbutylpiperidines, and benzamides is strongly counteracted by the anticholinergic drug scopolamine, while the antistereotypic effect of thioxanthenes, eg flupentixol is not, or only very slightly, influenced by concomitant treatment with anticholinergics.
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