Other significant adverse effects of testosterone supplementation include acceleration of pre-existing prostate cancer growth in individuals who have undergone androgen deprivation; increased hematocrit , which can require venipuncture in order to treat; and, exacerbation of sleep apnea .  Adverse effects may also include minor side-effects such as acne and oily skin, as well as, significant hair loss and/or thinning of the hair, which may be prevented with 5-alpha reductase inhibitors ordinarily used for the treatment of benign prostatic hyperplasia , such as finasteride .  Exogenous testosterone may also cause suppression of spermatogenesis , leading to, in some cases, infertility.  It is recommended that physicians screen for prostate cancer with a digital rectal exam and prostate-specific antigen (PSA) level before starting therapy, and monitor PSA and hematocrit levels closely during therapy. 
DHEA is a naturally occurring steroid hormone produced in the adrenal glands by both men and women. Production of it decreases with age. DHEA is not recommended for people under 40 years of age, unless DHEA levels are known to be low (<130 mg/dl in women and <180 mg/dl in men). Therapeutic doses of 10-50mg of DHEA are used by many mature individuals (age 40+) for increase in perceived physical and psychological well-being (improved quality of sleep, more relaxed, increased energy, better ability to handle stress, improved depressive state)1. For men or women who have either adrenal insufficiency or hypopituitarism, although gluco-and mineralocorticosteroid replacement is needed, 50 mg a day of DHEA is sufficient for replacement2. Studies have shown no dangerous side effects from DHEA supplementation when taken in normal recommended therapeutic doses3. With respect to potential increase of the urinary testosterone/epitestosterone ratio (T/E) through DHEA supplementation, studies support DHEA use of 50mg/day or less having only slightly affected levels for a short period of time (2–5 h) without exceeding the 6:1 current acceptable ratio for NANBF and the IPE. DHEA’s effectiveness as an anabolic or energy-producing agent remains unproven.